PHS 741 - Structural Biology

The course will provide students with the knowledge of NMR spectroscopy and X-ray crystallography techniques, used to determine three-dimensional structures and describe dynamics and interactions of macromolecules, such as proteins and nucleic acids. Using striking examples, the course will demonstrate the role of Structural Biology in our understanding of the basic relationships between structure, dynamics, and function of macromolecules. Specific examples will demonstrate applications of NMR spectroscopy and X-ray crystallography in structure-based drug discovery and design. The students will become familiar with the application of Structural Biology methods to describe and quantify interactions between macromolecules and small molecules. (Offered as needed.) 3 credits